hnRNPR Regulates MYB Expression Via Interacting with Enhancer lncRNA MY34UE-AS in Human Leukemia Cells
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Abstract
The heterogeneous nuclear ribonucleoprotein (hnRNP) family significantly influences the development and progression of various cancers, yet the specific role of its major member hnRNPR in leukemia is not yet understood. Our study discovered a long non-coding RNA (lncRNA) enhancer, known as MY34UE-AS, transcribed from the -34kb enhancer of the MYB gene. It has the ability to increase MYB expression in human leukemia cells. This study demonstrated that hnRNPR can bind to MY34UE-AS through its RRM2 domain. Overexpression of hnRNPR increased MYB expression and enhanced K562 cell proliferation and migration, while hnRNPR knockdown had the opposite effects. Further investigation revealed that MY34UE-AS is crucial for the aforementioned functions of hnRNPR. In summary, these findings suggest that hnRNPR plays a role in MYB regulation and the development of leukemia by interacting with MY34UE-AS.
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